RAMP-ing up Class-B GPCR ECD Structural Coverage

Class-B GPCR activation: is ligand helix-capping the key?

The class B family of G-protein-coupled receptors (GPCRs) regulates essential physiological functions such as exocrine and endocrine secretions, feeding behaviour, metabolism, growth, and neuro- and immuno-modulations. These receptors are activated by endogenous peptide hormones including secretin, glucagon, vasoactive intestinal peptide, corticotropin-releasing factor and parathyroid hormone. ...

Ramp-ing up allergies: Nramp1 (Slc11a1), macrophages and the hygiene hypothesis.

The ‘hygiene hypothesis’ suggests that a lack of infections favours the development of allergic disease. Mycobacteria and helminths are important in the hygiene hypothesis as infections caused by these agents generate regulatory mechanisms that can restore the immune balance. The hygiene hypothesis may be viewed as a complex multifactorial interaction between the environment and the genetic bac...

Sampling up the ramp

Ramp Up / Down Floating Point

Rapid Ramp-up for Statistical Machine Translation: Minimal Training for Maximal Coverage

This paper investigates optimal ways to get maximal coverage from minimal input training corpus. In effect, it seems antagonistic to think of minimal input training with a statistical machine translation system. Since statistics work well with repetition and thus capture well highly occurring words, one challenge has been to figure out the optimal number of “new” words that the system needs to ...